Brandon Aiyuk (high ankle sprain) will not play in Week 17

49ers wide receiver Brandon Aiyuk suffered a high ankle sprain during Saturday’s loss to the Cardinals and will not play in Week 17 against the Seahawks.

Fantasy Impact: 

The 49ers will also be without OT Trent Williams, who has a sprained elbow. Aiyuk had himself a fine rookie season, including leading the team in catches and yards. No George Kittle or Deebo Samuel obviously played into that, but still a good rookie season, nonetheless. At least Kittle is back to give San Francisco something on offense, but the team is ready to just play out the final game and move on to 2021. They “host” the Seahawks in Arizona on Sunday, with the Seahawks playing for the No. 1 seed in the NFC.

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