Week 6 vs. New York Giants
After a strong start to the season, James Cook had his worst game on the field and on the fantasy stat sheet. He had -4 yards rushing, but did manage three receptions for 25 yards. But overall it wasn't a good day for the second-year running back.
Cook faces the Giants who have an average run defense. The lack of a running game contributed to the Bills loss in London last week, so expect them to focus on running the ball better - meaning more than five carries for Cook.
Cook only ranks as a low-end RB2 for Week 6. Despite some good numbers early in the season, it seems the Bills running backs get lost every year, and that could be the case with Cook.