Colts sign QB Brian Hoyer

The 49ers will have wide receiver Brandon Aiyuk and left tackle Trent Williams against the Jets on Monday night, but they will not have running back Christian McCaffrey.

Jordan Mason, Patrick Taylor and Isaac Guerendo are the available backs for the Niners.

Definitely a shocker and likely a big blow to fantasy owners. According to the story, McCaffrey said on Friday that he had no doubt he would play and there was plenty of optimism from head coach Kyle Shanahan and General Manager John Lynch as well. McCaffrey missed most of the summer with a calf injury and is listed with an Achilles issue as well, the story said. Mason had a great camp and seemed to get a lot of attention from coaches this summer, and likely should get a bulk of the workload tonight against the Jets. Hopefully CMC owners backed themselves up during drafts by nabbing Mason. If Mason is still on your wire, he's worth picking up for any team in case CMC's issues are longer term. Taylor and Guerendo could get work for the Niners as well - if you're in a pinch losing CMC. From the Jets side, Braelon Allen and Israel Abanikanda could see touches behind Breece Hall.

Raheem Mostert has a chest injury and De’Von Achane sustained an ankle ailment, the Dolphins’ Monday injury report revealed.

Related players: Jeff Wilson, Jaylen Wright

With a short week ahead and a game on Thursday night against the Bills, the two will need to be monitored by fantasy owners. The story went on to say while the team did not practice Monday, both Mostert and Achane were deemed they would’ve been non-participants if practice were held.

Via Ian Rapoport of NFL Media, former Giants and Chiefs receiver Kadarius Toney has signed with the Browns. He’ll be joining the team’s practice squad.

Toney also had visited the Seahawks since being released by the Chiefs two weeks ago, the story said. For now, Toney is best left to very deep leagues and dynasty leagues. As the story puts it, his commitment and focus continues to be an issue in his career.