Mattison has proved over and over again that he is a legitimate fantasy asset when Cook is forced to miss games, including his 44-yard, two-touchdown performance in Week 3. He currently stands as the RB20 (before MNF) on the week, despite only logging 39% of the offensive snaps.
Mixon was still in on 66% of the Bengals' offensive snaps, but his last touch came on the very last play of the third quarter. The rest could very well have been precautionary, as Cincinnati took over with 10:00 left in the fourth quarter and proceeded to run the ball 11 times in a row in order to use up the clock, up by 15 points. Mixon's Week 4 opponents, the Miami Dolphins, have been relatively stout against the run but also just allowed a 14-121-1 receiving line to Bills running backs in Week 3.
Pelissero continued, "this means ligament damage in his ankle. By and large, these are multiple week types of injuries." The hope is that he will not need surgery, but it is highly unlikely he will suit up for Week 4.
The Patriots' fantasy options were already nothing to get excited about with Mac Jones at the helm, so sticking 36-year-old Brian Hoyer back there isn't going to move the needle. In Hoyer's last full start, he went 15-of-24 for 130 yards and an interception and a fumble in Week 4 of the 2020 season.