The veteran running back injured his left thumb late in the first half against the Bengals on Sunday while falling out of bounds.
McCoy caught a short pass from Tyrod Taylor for an 8-yard gain and headed to the sideline with 1:51 remaining in the second quarter. He got hit by Bengals safety Shawn Williams and tried to brace his fall with his left hand. McCoy popped back up, but pointed to the Bills staff to remove him from the game. The Bills ruled him out early in the second half.