Week 14 vs. Jacksonville Jaguars
As can happen with Derrick Henry, he was game-scripted out of a large role with the Titans trailing the Eagles virtually the entire game in Week 13. Henry has some of fantasy's best usage for any player except in one scenario: the Titans falling behind early and being forced to pass. That is unlikely to happen in Week 14 when the Titans host the Jaguars' below-average run defense, meaning Henry is set up for his typical huge workload. Even with some slow weeks mixed in along the way, Henry leads the NFL in carries, is third in rushing, and has 10 touchdowns on the year. He is a surefire starter and clear RB1 in Week 14.