That injury could put Kittle's status for Week 2 against the New York Jets up in the air depending on how this week plays out, coach Kyle Shanahan said.
"We'll see how he comes in on Wednesday," Shanahan said. "He was a little sore today but we'll wait to see how he is on Wednesday to see if he's able to practice or be able to go this week. We know there will be some question."
Related players: Jordan Reed
The story said Kittle came up hobbling near the end of the first half after taking a hit from Cardinals safety Budda Baker. Kittle was able to walk to the sideline, where he was evaluated by medical staff before heading to the locker room early. But Kittle returned after halftime and seemed to make it through the game OK, though he had no catches and was not targeted in the final two quarters after posting four catches for 44 yards on five targets in the first half. Reed would be next up as the TE1 if Kittle can't go.