Squirrel Patrol's Week 5 NFL DFS Tournament Strategy & Picks (DraftKings & FanDuel)

Oct 03, 2025
Squirrel Patrol's Week 5 NFL DFS Tournament Strategy & Picks (DraftKings & FanDuel)

Week 5 brings a 10-game main slate on Sunday, with another international game Sunday morning and four teams on a bye. Both FanDuel and DraftKings have posted huge prize pools, including two Millionaire Maker tournaments on DraftKings.

Game totals continue to be tightly bunched, with every matchup on the slate sitting between 40.5 and 49.5 points. We see some large spreads, however, with Detroit (-10.5) and Arizona (-7.5) both favored by double-digits. Injuries, particularly at running back, continue to shape the DFS landscape, and several running backs stand out as injury-related values. Notably, two of this year’s standout fantasy performers are off the slate, with Christian McCaffrey and Puka Nacua both playing Thursday night.

Let’s break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards this Sunday.

Quarterbacks

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