Week 16 vs. Buffalo Bills
The Patriots have the highest implied team total in Vegas this week at 29.5 points, and the Bills defense is a run funnel, ranking seventh in aFPA versus QBs but dead last in aFPA versus RBs. Plus, Rex Burkhead sprained his knee and is likely out. That means Mike Gillislee should be active again for the first time in weeks, but you're banking on the Patriots blowing out the Bills quickly and resting starting RB Dion Lewis for Gillislee to be a productive part of the offense and a sneaky fantasy start. Because even when Gillislee was active, he went six straight weeks without reaching six PPR points. Woof. Starting Gillislee this week in fantasy championships is probably the biggest gamble you can take that might also have huge upside.