Week 1 vs. Arizona Cardinals
Deebo Samuel had a nice rookie season last year with 802 yards and three touchdowns on 57 receptions. He should see an uptick from his 81 targets with Emmanuel Sanders off the roster and some natural progression from him and quarterback Jimmy Garoppolo. Samuel is fierce after the catch, and while he suffered an offseason injury, rumors are he’ll play in Week 1. Tough kid.
He should have a nice matchup against the Cardinals, who ranked 24th in aFPA to opposing wide receivers last year. Watch the inactives list closely to make sure he’s going to play though. Even if he’s active, having the question marks this late in the game makes fantasy owners uneasy. If you can look elsewhere until we see him healthy and productive, that might be the right approach. We have him ranked as a low-end WR3 to start the season with the question marks.
UPDATE: Deebo is out, so adjust your lineups accordingly. Brandon Aiyuk and Kendrick Bourne should benefit and become long-shot WR3 options.