Week 13 vs. San Diego
Jameis Winston stared the tough Seahawks' secondary in the face and delivered a strong 220-yard, two-touchdown performance. It wasn't his best game of the season, but those are good numbers against a good secondary.
He gets another test this week against the Chargers, who lead the league in forced interceptions. But this defense isn't completely on lockdown, as they've allowed five 300+ yard passing games.
If you absolutely need Winston this week, he's not the worst option, but it might be worth looking at waivers to see if you can find a replacement.