The good news is E.J. Manuel is still young and the Bills are publicly saying there is a quarterback competition to decide who will be the starter. The potential word is still being thrown around the Buffalo camp. Manuel has shown some positives during his first two seasons, but there might not be enough to keep him relevant in the NFL.
New head coach Rex Ryan did not select Manuel, so it is hard to really get a feel for how Ryan feels about him. When you watch film, you don't see a lot of things that make you say Manuel has a good chance to succeed as a starting quarterback in the league. There are too many mistakes mentally and he has also struggled physically, although he did gain some weight with the intention of it keeping him healthy.
Manuel might still get a chance with Buffalo, but Matt Cassel will have to either fail miserably or get hurt. Even if he does get another chance, we are confident the results won't be much different. Manuel has very little fantasy value, even if he is the starter Week 1.