DeAngelo Williams is dealing with a knee injury, which may have prompted the move. Williams had a great rookie season but fell out of favor in Buffalo when he gained a lot of weight in the offseason. He's a player to monitor as the season continues to wear on.
BUF RB Karlos Williams - 2016 Fantasy Football Outlook
Karlos Williams was a major contributor to the Buffalo running game and might have been the Bills' most effective back. He averaged 5.9 yards per carry and produced 9 touchdowns. Williams will probably have more touchdown opportunity in goal line situations with his 230-pound frame.
Williams will miss the first four games of the season because of violating the NFL’s substance policy. Several things could happen from this, one being his job as the backup to LeSean McCoy might not be available when he returns. He also could be out of shape, like it was reported this summer.
2016 Bottom Line
Williams blew it. After an impressive rookie season, he took a major step back with the suspension. He still has some fantasy value, but his ADP has fallen to 163 and he is going a lot later round than he should. When he returns, he should be a part of the Bills offensive plans, but drafting him in the later rounds is probably an accurate assessment. Keep an eye on the fact the Bills brought in Reggie Bush although he would probably have a different role than Williams