Wide receiver Michael Crabtree was held out of practice Wednesday due to a calf injury, the 49ers disclosed on their mandatory participation report.
It's the second leg injury for Crabtree from the start of training camp up to the 49ers' first regular-season game. He sustained a hamstring injury that kept in out of action for 16 days during training camp. Crabtree's availability for the regular-season opener on Sunday against the Dallas Cowboys is not known.
It is a bit worrisome that Crabtree is sitting out of practice this close to the start of Week 1, but he has plenty of time to get reps provided this rest is precautionary. We should know more tomorrow.