The Texans will be without two tight ends for Sunday's game against Indianapolis.
Pro Bowl tight end Owen Daniels suffered a torn anterior cruciate ligament in his right knee and will undergo season-ending surgery.
Rookie James Casey underwent arthroscopic knee surgery Monday and will miss at least one game, coach Gary Kubiak said. Casey could return for the Nov. 23 game against Tennessee.
Daniels suffered the injury while running a pass route in the second quarter of Sunday's 31-10 victory over the Buffalo Bills.
Daniels, who went to the Pro Bowl last season, was off to the best start of his career with 41 catches.
"It doesn't feel good," Daniels said after Sunday's game. "I'm concerned. I've hurt my knee before."
Surgery on a torn ACL generally requires an eight-month rehabilitation period.
Joel Dreesen will replace Daniels in the starting lineup.