San Francisco 49ers
K Joe Nedney (right knee), T Joe Staley (fibula)
LB Navorro Bowman (hamstring), LB Takeo Spikes (hand), LB Patrick Willis (hand)
TE Nate Byham (shoulder), G Mike Iupati (shoulder), RB Brian Westbrook (not injury related), RB DeShawn Wynn (ankle)
San Diego Chargers
WR Patrick Crayton (wrist), LB Larry English (foot)
TE Antonio Gates (toe, foot)
WR Malcom Floyd (hamstring), LB Brandon Siler (ribs), G Louis Vasquez (neck), S Pat Watkins (knee)
DE Jacques Cesaire (knee), DT Antonio Garay (ankle), T Marcus McNeill (knee), WR Legedu Naanee (hamstring)
For the 49ers, Jeff Reed will again handle kicking duties.
For the Chargers, look for Randy McMichael to start at TE with Gates doubtful. Floyd will be a game-time decision, although he sounds likely to play. Vincent Jackson is the healthiest Chargers wideout.