Running back Ryan Mathews and right tackle Halapoulivaati Vaitai have been ruled out. Both have MCL sprains.
The good news for the Eagles comes from the fact that all other injured players will be able to go (according to Pederson), including running back Darren Sproles, who suffered a rib injury against the Seahawks, the story said. Smallwood seems like he could be in store for a majority of the carries. Kenjon Barner likely factors in as well.