Middle linebacker Gary Brackett and cornerback Kelvin Hayden did not travel with the Indianapolis Colts to Arizona where they will play the Cardinals on Sunday night.
Brackett injured his left knee late in last Sunday's victory at Miami Dolphins. Hayden hurt his hamstring.
Both were held out of practice this week.
Freddy Keiaho likely will replace Brackett, the defensive captain, in the starting lineup. It's uncertain who will replace Hayden for the Colts in the secondary.