CB Marcus Burley (hand), RB Derrick Coleman (concussion), DT Jordan Hill (quadricep), C Patrick Lewis (ankle), LB Nick Moody (ankle)
DE Demarcus Dobbs (shoulder)
DE Cliff Avril (ankle), G Justin Britt (hip), S Kam Chancellor (shoulder), DE Frank Clark (hamstring), T Garry Gilliam (ankle), WR Tyler Lockett (hip), RB Marshawn Lynch (hamstring), CB Richard Sherman (ankle), CB Tye Smith (hip), LB Bobby Wagner (pectoral)
San Francisco 49ers
G Alex Boone (shoulder), LB Navorro Bowman (shoulder), LB Ahmad Brooks (shoulder), RB Reggie Bush (calf), TE Vernon Davis (knee), WR Bruce Ellington (calf), TE Vance McDonald (chest), S Eric Reid (chest), T Joe Staley (knee), G Brandon Thomas (ankle)
Marshawn Lynch is probable, so we expect another big workload. Anquan Boldin and Carlos Hyde are both iffy. Given the matchup against a tough Seattle defense, we recommend shying away from both players if possible. It looks like Reggie Bush will make his return, though he has been unable to stay healthy for very long this year.