CB Tarell Brown (ribs), G Mike Iupati (knee), WR Quinton Patton (foot)
TE Garrett Celek (hamstring), WR Mario Manningham (knee), DT Ray McDonald (ankle)
DT Quinton Dial (ankle), RB Frank Gore (ankle), QB Colin Kaepernick (back), LB Dan Skuta (foot), DT Justin Smith (shoulder)
TE Jordan Reed (concussion)
DE Stephen Bowen (knee), S Jose Gumbs (ankle), RB Darrel Young (hamstring)
CB E.J. Biggers (knee), CB Josh Wilson (toe)
Logan Paulsen and Fred Davis will try to fill in for Reed in a not-so-favorable matchup against the 49ers. Paulsen had a TD in Week 10 vs. the Vikings but only finished with three yards, so neither is really a safe play. For the 49ers, WR Mario Manningham is questionable while QB Colin Kaepernick and RB Frank Gore are probable.