Giants coach Tom Coughlin said Randle has dealt with tendinitis in his knee for some time, and did not seem concerned that it would be a long term issue.
"We thought he was doing pretty good last night," Coughlin said.
Randle participated at the beginning of practice, but then came off and was seen icing both knees.
This will be a big season for Randle. Last season, he turned in his most productive season as a pro, bringing in 71 catches for 938 yards and three touchdowns. The number of catches more doubled the 60 combined grabs he had in his first two seasons. But Randle was also benched twice, and how many targets he will get in 2015 if the Giants have both Odell Beckham Jr. and Victor Cruz fully healthy and on the field is a question, the story said.