Colts wide receiver Reggie Wayne and running back Donald Brown have been injured in Indianapolis' game against the St. Louis Rams.
Both were injured in the second quarter Sunday and the team said it was questionable whether they would return.
Wayne had six receptions for 70 yards and a 6-yard touchdown before leaving with a strained groin muscle. He caught four passes for 61 yards on the opening possession.
Brown left with a sprained shoulder. Joseph Addai's backup, he had two carries for 58 yards, including a 45-yard run in the first quarter.