Brown was listed as the No. 4 running back on the depth chart and was inactive on Sunday in the season opener. His release has made room for Marcell Dareus, who was activated after serving his one-game suspension.
The Bills traded a fourth-round pick in 2014 to acquire Brown from the Philadelphia Eagles, but he never panned out in Buffalo. He had trouble holding onto the ball and was not a reliable back for Rex Ryan and the Bills.