Bills 'cautiously optimistic' that LeSean McCoy (hamstring) will be ready for Week 1

Buffalo Bills coach Rex Ryan told reporters Thursday he is "cautiously optimistic" that running back LeSean McCoy can return in time for the Bills' regular-season opener Sept. 13 against the Indianapolis Colts.

McCoy suffered a hamstring injury in a joint practice Tuesday with the Cleveland Browns. Ryan did not reveal the results of an MRI on McCoy's hamstring, but had said after Tuesday's practice that McCoy's hamstring was intact and that no separation from the bone occurred.

Fantasy Impact: 

It’s safe to say that McCoy’s situation hasn’t improved. Sure, he’s going to a run-heavy system, so carries shouldn’t be a problem, but the Buffalo offense isn’t likely to be as efficient as Chip Kelly’s offense in Philadelphia. Throw in an offensive coordinator (Greg Roman) who isn’t known for utilizing his running backs in the passing game and it’s likely that McCoy’s red zone chances and targets will both decrease in 2015. Now he has a hamstring injury that could affect his Week 1 availability. We're steering clear of McCoy in the 2nd round.

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